Изследователска дейност

Интердисциплинарни изследвания в областта на органичния синтез и структурния анализ на органични съединения чрез експериментални методи (вибрационна, ултравиолетова и флуоресцентна спектроскопия, инфрачервен линеен дихроизъм и др.) и теоретични методи (съвременни неемпирични квантово-химични и докинг методи).

Обекти на изследванията:
• биологично активни органични съединения;
• аниони и радикал-анионни интермедиати;
• фитопродукти;
• протеини и липиди;
• съединения с приложение в нелинейната оптика и оптоелектрониката;
• молекули, ориентирани в нематични течно-кристални матрици.

Научните изследвания са насочени към изясняване на механизма на органични реакции; молекулна структура и тавтомерия; вибрационни и оптични свойства на органичните съединения; взаимодействието с биологични мишени; лекарствено подобие и очаквана токсичност; връзката структура–биологична активност.

Основните области на приложение на разработените материали обхващат медицината, по-специално лечението на ракови, невродегенеративни, вирусни и паразитни заболявания. Провеждат се и теоретични изследвания на фотофизични, хирооптични и транспортни свойства на органични системи с потенциално приложение в нелинейната оптика и оптоелектрониката.

Нова насока в научната дейност на лабораторията е идентифицирането и охарактеризирането на разнообразни материали от български и свързани с България археологически и художествени обекти посредством аналитични методи.

ПЕРСОНАЛ

Ръководител:

доц. д-р Бистра Стамболийска

02 9606 406

127

bistra.stamboliyska@orgchm.bas.bg

Име	Стая	Телефон	Е-поща*
доц. д-р Бистра Стамболийска, ръководител	406	127	bistra.stamboliyska
проф. д-р Деница Панталеева	303	106	denitsa.pantaleeva
доц. д-р Евелина Велчева	406	127	evelina.velcheva
доц. д-р Марин Рогожеров	101	150	marin.rogozherov
доц. д-р Милена Спасова	219	193	milena.spassova
доц. д-р Надежда Маркова	220	197	nadezhda.markova
доц. д-р Неда Анастасова	303	106	neda.anastassova
доц. д-р Симеон Стоянов	413	138	simeon.stoyanov
доц. д-р Снежана Бакалова	212	126	snezhana.bakalova
гл. ас. д-р Мария Аргирова	413	138	maria.argirova
ас. Илонка Генева	304	103	ilonka.geneva
химик Ангел Минков	303	106	angel.minkov
химик Георги Тиролски	303	106	georgi.tirolski
химик Кристиан Митин	304	103	Kristian.Mitin
химик Николай Лумов	304	103	nikolay.lumov
Асоциирани членове
Акад. проф. дн Иван Юхновски	305		ivan.juchnovski
проф. дн Хозе Канети	212	126	jose.kaneti
доц. д-р Емилия Чернева	Фармацевтичен факултет, МУ-София	(+359-2) 9236-507	cherneva@pharmfac.mu-sofia.bg

*Електронната поща се образува след добавяне на '@orgchm.bas.bg' към името

Текущи Проекти

Публикации

2025

Chemistry & Biodiversity,
22(7), e202500259

Quantum Chemical and Metabolomic Characterization of Inhibitory Activity of Procyanidins and Flavonol Glucosides from Graptopetalum paraguayense E. Walther against Nonstructural Proteins of SARS-CoV-2

Bulgarian Journal of Agricultural Science,
31(5), 997–1011

Phytochemical screening, anti-herpes simplex virus and antibacterial activities of various fractions, obtained from Graptopetalum paraguayense E. Walter extract

Journal of the Electrochemical Society,
172(6), 06550

Conversion of 1-alkylated 5(6)-nitro-1H-benzimidazoles into Radical Anions and Characterization of Their Bioreductive Potential

Archives of Biochemistry and Biophysics,
764, 110245

New metal complexes of 1H-benzimidazole-2-yl hydrazones: Cytostatic, proapoptotic and modulatory activity on kinase signaling pathways

Computational and Theoretical Chemistry,
1254, 115491

Radical scavenging mechanism of 1H-benzimidazole-2-yl hydrazones and kinetics with physiologically relevant radicals: A computational study

Bioorganic Chemistry,
164, 108920

Benzimidazole-based hybrids as inhibitors of EGFR/VEGFR-2 and their combinations with other enzymes: design, synthesis, and activity

Applied Science,
15, 9367

The Characterization of Commercial and Historical Textiles using a Combination of Micro-Chemical, Microscopic and Infrared Spectroscopic Methods

Chemical Neuroscience,
16, 1161-1181

Exploring the Potential of Indole-3-acetic Acid Arylhydrazone Hybrids for Parkinson’s Disease Treatment: A Comprehensive Evaluation of Neuroprotective, MAOB Inhibitory, and Antioxidant Properties

J. Mol. Struct.,
1311, 138408

Synthesis of new [6]helicene derivatives for OLED applications. Experimental photophysical and chiroptical properties and theoretical investigation

Molecules,
29(23), 5711

Behavioral and Biochemical Effects of an Arylhydrazone Derivative of 5-Methoxyindole-2-Carboxylic Acid in a Scopolamine-Induced Model of Alzheimer’s Type Dementia in Rat

Molecules,
29(15), 3475

Recent Advances in the Application of Nitro(het)aromatic Compounds for Treating and/or Fluorescent Imaging of Tumor Hypoxia

Spectrochimica Acta Part A,
304, 123287

Phase behaviour and structural properties of SOPC model lipid system in a sucrose solution

Minerals,
14(11), 1115

Materials and Techniques of the Mural Paintings in the Church-Ossuary of the Rila Monastery, Bulgaria

Minerals,
14, 374

Multi-Analytical Analysis of Decorative Color Plasters from the Thracian Tomb near Alexandrovo, Bulgaria

Pharmaceutics,15(6),
1753

Novel Fluorescent Benzimidazole-Hydrazone-Loaded Micellar Carriers for Controlled Release: Impact on Cell Toxicity, Nuclear and Microtubule Alterations in Breast Cancer Cells

Molecules,28,
5034

Fused Triazinobenzimidazoles Bearing Heterocyclic Moiety: Synthesis, Structure Investigations, and In Silico and In Vitro Biological Activity

Vibrational Spectroscopy,128,
103580

Characterization of art materials and degradation processes in the exterior wall paintings of the main church of Rila Monastery, Bulgaria

Molecules,28,
6109

Theoretical Assessment of the Ligand/Metal/Quadruplex Recognition in the Non-Canonical Nucleic Acids Structures

Journal of Molecular Structure,1271,
133927

Anion and radical anion products of flutamide studied by IR spectra and density functional calculations

Comptes Rendus de L'Academie Bulgare des Sciences,76(3),
377–387

The Wall Paintings in the Russian Church St. Nicholas in Sofia: a Technological Study by Integrated Analytical Approach

Molecules,28(1),
291

Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones

Journal of Physical Chemistry B,127(20),
4364-4373

Radical Scavenging Mechanisms of 1-Arylhydrazone Benzimidazole Hybrids with Neuroprotective Activity

Antioxidants,12(4),
977

RNew Indole-3-Propionic Acid and 5-Methoxy-Indole Carboxylic Acid Derived Hydrazone Hybrids as Multifunctional Neuroprotectors

Journal of Molecular Structure
1294,
136388

Further findings concerning 2,6-diiodo-3,4,5-trimethoxybenzoic acid (Part II)

Molecules,27,
7577

Small Heterocyclic Ligands as Anticancer Agents: QSAR with a Model G-Quadruplex

Pharmacia,69(1),
113–123

Potential of Hydroxybenzoic Acids from Graptopetalum paraguayense for Inhibiting of Herpes Simplex Virus DNA Polymerase – Metabolome Profiling, Molecular Docking and Quantum-chemical Analysis

Antioxidants
11,
884

Study on the Neuroprotective, Radical-Scavenging and MAO-B Inhibiting Properties of New Benzimidazole Arylhydrazones as Potential Multi-Target Drugs for the Treatment of Parkinson’s Disease

RSC Advances, 11,
39848

New 1H-benzimidazole-2-yl hydrazones with combined antiparasitic and antioxidant activity

Chemico-Biological Interactions
345,
109540

1H-benzimidazole-2-yl hydrazones as tubulin-targeting agents: Synthesis, structural characterization, anthelmintic activity and antiproliferative activity against MCF-7 breast carcinoma cells and molecular docking studies

Neural Regeneration Research
16(11),
2299-2309

Evaluation of the combined activity of benzimidazole arylhydrazones as new anti-Parkinsonian agents: monoamine oxidase-B inhibition, neuroprotection and oxidative stress modulation

The European Physical Journal Plus
136,
733

Three Persian Qajar paintings from the National Gallery Sofia. Study of the technology and the composition materials for the purpose of dating and conservation evaluation

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
247,
119087

The altar wall paintings of the catholicon “The Nativity of the Virgin”, Rila Monastery, Bulgaria: Identification of the painting materials by means of vibrational spectroscopic techniques complemented by EDX, XRD and TGA analysis

Journal of Molecular Structure
1226,
129303

Spectral behavior peculiarities of the carboxyl functional group in iodine encirclement - the case of 2,6-diiodo-3,4,5-trimethoxybenzoic acid

Photochemistry and Photobiology
97 (4),
710-717

Binding Expedient of 2-carbamido-1,3-indandione to Nucleic Acids: Potential Fluorescent Probe

Journal of Biomolecular Structure and Dynamics
39(15),
5563-5578

Chemical evolution: from formamide to nucleobases and amino acids without the presence of catalyst

International Journal of Quantum Chemistry
121 (19),
e26760

Effect of external electric field on the tautomeric equilibrium and structure of 2-carbamido-1,3-indandione

The Journal of Physical Chemistry Letters, 11 (4),
1390-1396

Boron-Doped Polycyclic Aromatic Hydrocarbons: A Molecular Set Revealing the Interplay between Topology and Singlet Fission Propensity

Chemical Physics, 535,
110763

Combined infrared spectroscopic and computational study on simpler capsaicin derivatives and their anion intermediates in the scavenging of free radicals

Pharmacological Reports
72,
846–856

New benzimidazole-aldehyde hybrids as neuroprotectors with hypochlorite and super oxide radical scavenging activity

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
234,
118279

Spectroscopic and in silico study on the conversion of N,N'-disubstituted hydrazone derivatives of 5-nitrobenzimidazole-2-thione into anion and radical anion products: Implications in hepatotoxicity

Journal of Physical Chemistry B, 123,
622-630

Tautomerism of Inosine in Water: Is It Possible?

Journal of Molecular Structure,
1198,
126880

Experimental and theoretical conformational studies of hydrazine derivatives bearing a chromene scaffold

Spectrochimica Acta Part A, 192,
263-274

Synthesis, spectroscopic and TD-DFT quantum mechanical study of azo-azomethine dyes. A laser induced trans-cis-trans photoisomerization cycle

Bioorganic Chemistry,
80,
693-705

Synthesis and DNase I inhibitory properties of some 5,6,7,8-tetrahydrobenzo[4,5] thieno[2,3-d]pyrimidines

Органични материали в художествени и археологически обекти