Research interests

The basic research topics are in the interdisciplinary field of the structural organic analysis, carried out experimentally (by means of vibrational spectroscopy and X-ray diffraction) as well as theoretically (on the basis of modern non-empirical quantum-chemical methods). The research object is a large series of organic compounds (biologically active compounds, food additives etc., including isotope labelled ones), their hydrogen-bonded complexes as well as anions-intermediates in important chemical reactions. The results obtained make it possible to follow the spectral and structural variations, caused by the conversion of organic molecules into complexes and anions, as well as elucidation of the structure – activity relationship.

Тhe scientific expertise of the Group of Molecular Electronic Spectroscopy covers experimental investigations by UV-VIS absorption, steady-state and dynamic luminescent spectroscopy aiming at elucidation of the relationship between the structure (chemical and electronic) of conjugated organic compounds and the deactivation processes of their singlet and triplet electronically excited states. The photophysical and photochemical properties of more than 800 organic compounds and dyes are studied, including pyrazolones, oxazolones, benzthiazoles, triazoles, benzopyranes, benzylidenephthalides, indanediones, indenones, coumarines and izo-coumarines, naphthiridines, perylene dyes, acridines, pyrylium and xanthilium dyes, porphyrins, merocyanine and asymmetric monomethincyanine dyes, etc. Our research is directed to the possible application of the studied compounds as fluorescent markers for polymers, biopolymers and nanoparticles, and as bio- and chemical sensors.

The research of the Group of Vibrational spectroscopy is focused on infrared linear dichroism of molecules oriented in nematic liquid crystal matrices and infrared ellipsometric studies of thin films and self-assembled monolayers on metallic and silicon surfaces.

A recent research topic of the Laboratory “Structural Organic Analysis” is identification and study of Bulgarian historical and artistic objects by means of analytical techniques. The aim of the research is to support the preservation of the Bulgarian cultural heritage.

LABORATORY MEMBERS

Head:

Assoc. Prof. Bistra Stamboliyska

02 9606 406

127

bistra.stamboliyska@orgchm.bas.bg

Name	Room	Phone	Е-mail*
Assoc. Prof. Bistra Stamboliyska, PhD, Head	406	127	bistra.stamboliyska
Prof. Denitsa Pantaleeva, PhD	303	106	denitsa.pantaleeva
Assoc. Prof. Evelina Velcheva, PhD	406	127	evelina.velcheva
Assoc. Prof. Marin Rogojerov, PhD	101	150	marin.rogozherov
Assoc. Prof. Milena Spassova, PhD	219	193	milena.spassova
Assoc. Prof. Snezhana Bakalova, PhD	212	126	snezhana.bakalova
Assoc. Prof. Nadezhda Markova, PhD	220	197	nadezhda.markova
Assist. Prof. Neda Anastasova, PhD	303	106	neda.anastassova
Assist. Prof. Simeon Stoyanov, PhD	413	138	simeon.stoyanov
Assist. Prof. Maria Argirova, PhD	413	138	maria.argirova
Assistant Nikolay Lumov	304	103	nikolay.lumov
Chemist Georgi Tirolski	303	106	Georgi.Tirolski

*The e-mail is formed after adding '@ orgchm.bas.bg' to the name

Projects

Selected group publications

2023

Pharmaceutics,15(6),
1753

Novel Fluorescent Benzimidazole-Hydrazone-Loaded Micellar Carriers for Controlled Release: Impact on Cell Toxicity, Nuclear and Microtubule Alterations in Breast Cancer Cells

Molecules,28,
5034

Fused Triazinobenzimidazoles Bearing Heterocyclic Moiety: Synthesis, Structure Investigations, and In Silico and In Vitro Biological Activity

Vibrational Spectroscopy,128,
103580

Characterization of art materials and degradation processes in the exterior wall paintings of the main church of Rila Monastery, Bulgaria

Molecules,28,
6109

Theoretical Assessment of the Ligand/Metal/Quadruplex Recognition in the Non-Canonical Nucleic Acids Structures

Journal of Molecular Structure,1271,
133927

Anion and radical anion products of flutamide studied by IR spectra and density functional calculations

Comptes Rendus de L'Academie Bulgare des Sciences,76(3),
377–387

The Wall Paintings in the Russian Church St. Nicholas in Sofia: a Technological Study by Integrated Analytical Approach

Molecules,28(1),
291

Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones

Journal of Physical Chemistry B,127(20),
4364-4373

Radical Scavenging Mechanisms of 1-Arylhydrazone Benzimidazole Hybrids with Neuroprotective Activity

Antioxidants,12(4),
977

RNew Indole-3-Propionic Acid and 5-Methoxy-Indole Carboxylic Acid Derived Hydrazone Hybrids as Multifunctional Neuroprotectors

Journal of Molecular Structure
1294,
136388

Further findings concerning 2,6-diiodo-3,4,5-trimethoxybenzoic acid (Part II)

Molecules,27,
7577

Small Heterocyclic Ligands as Anticancer Agents: QSAR with a Model G-Quadruplex

Pharmacia,69(1),
113–123

Potential of Hydroxybenzoic Acids from Graptopetalum paraguayense for Inhibiting of Herpes Simplex Virus DNA Polymerase – Metabolome Profiling, Molecular Docking and Quantum-chemical Analysis

Antioxidants
11,
884

Study on the Neuroprotective, Radical-Scavenging and MAO-B Inhibiting Properties of New Benzimidazole Arylhydrazones as Potential Multi-Target Drugs for the Treatment of Parkinson’s Disease

RSC Advances, 11,
39848

New 1H-benzimidazole-2-yl hydrazones with combined antiparasitic and antioxidant activity

Chemico-Biological Interactions
345,
109540

1H-benzimidazole-2-yl hydrazones as tubulin-targeting agents: Synthesis, structural characterization, anthelmintic activity and antiproliferative activity against MCF-7 breast carcinoma cells and molecular docking studies

Neural Regeneration Research
16(11),
2299-2309

Evaluation of the combined activity of benzimidazole arylhydrazones as new anti-Parkinsonian agents: monoamine oxidase-B inhibition, neuroprotection and oxidative stress modulation

The European Physical Journal Plus
136,
733

Three Persian Qajar paintings from the National Gallery Sofia. Study of the technology and the composition materials for the purpose of dating and conservation evaluation

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
247,
119087

The altar wall paintings of the catholicon “The Nativity of the Virgin”, Rila Monastery, Bulgaria: Identification of the painting materials by means of vibrational spectroscopic techniques complemented by EDX, XRD and TGA analysis

Journal of Molecular Structure
1226,
129303

Spectral behavior peculiarities of the carboxyl functional group in iodine encirclement - the case of 2,6-diiodo-3,4,5-trimethoxybenzoic acid

Photochemistry and Photobiology
97 (4),
710-717

Binding Expedient of 2-carbamido-1,3-indandione to Nucleic Acids: Potential Fluorescent Probe

Journal of Biomolecular Structure and Dynamics
39(15),
5563-5578

Chemical evolution: from formamide to nucleobases and amino acids without the presence of catalyst

International Journal of Quantum Chemistry
121 (19),
e26760

Effect of external electric field on the tautomeric equilibrium and structure of 2-carbamido-1,3-indandione

The Journal of Physical Chemistry Letters, 11 (4),
1390-1396

Boron-Doped Polycyclic Aromatic Hydrocarbons: A Molecular Set Revealing the Interplay between Topology and Singlet Fission Propensity

Chemical Physics, 535,
110763

Combined infrared spectroscopic and computational study on simpler capsaicin derivatives and their anion intermediates in the scavenging of free radicals

Pharmacological Reports
72,
846–856

New benzimidazole-aldehyde hybrids as neuroprotectors with hypochlorite and super oxide radical scavenging activity

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
234,
118279

Spectroscopic and in silico study on the conversion of N,N'-disubstituted hydrazone derivatives of 5-nitrobenzimidazole-2-thione into anion and radical anion products: Implications in hepatotoxicity

Journal of Physical Chemistry B, 123,
622-630

Tautomerism of Inosine in Water: Is It Possible?

Journal of Molecular Structure,
1198,
126880

Experimental and theoretical conformational studies of hydrazine derivatives bearing a chromene scaffold

Spectrochimica Acta Part A, 192,
263-274

Synthesis, spectroscopic and TD-DFT quantum mechanical study of azo-azomethine dyes. A laser induced trans-cis-trans photoisomerization cycle

Bioorganic Chemistry,
80,
693-705

Synthesis and DNase I inhibitory properties of some 5,6,7,8-tetrahydrobenzo[4,5] thieno[2,3-d]pyrimidines