Research |
Structural analysis and stereochemistry structural analysis of small and medium size molecules conformation and configuration; stereochemistry of compounds with central and planar chirality; new synthetic and natural biologically active compounds and mixtures - flavones, terpenoids, alkaloids, carbohydrates, antibiotics, nucleotides, etc.; steric interactions by 13Ρ NMR spectroscopy; structure and chemistry of phosphorus-containing compounds; structural analysis and oxidation stability of fats and oils - fatty acids and triacylglyceroles; linear and branched fluorescent polymers with application in optoelecrtonics.
Molecular mobility classic dynamic NMR, nuclear relaxation methods and gradient NMR spectroscopy; EXSY mixing time optimization; determination of exchange rate constants and thermodynamic parameters in complex multisite exchange system; DOSY; tautomeric and conformational equilibria; fluxtional isomerisation.
Supramolecular aggregates and complexes molecular recognition with cyclodextrines; structure and composition of surfactant solutions; determination of the critical micelle concentration; gradient NMR spectroscopy for drop size distribution analysis in food type emultions (water-in-oil and oil-in-water); colloid and water soluble polymers as drug delivery systems; mechanisms for drug immobilization in the polymer matrix.
Computer programs for automatic multiplets analysis; signal to noise enhancement in NMR spectra; determination of correlation times and activation energies of the overall and internal molecular reorientation; 13Ρ chemical shifts prediction for natural compounds using spectral databases.
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