Laboratory Nuclear Magnetic Resonance

Galya Ivanova

Assoc. Prof. Dr.
Galya Ivanova

Institute of Organic Chemistry
with Centre of Phytochemistry
Bulgarian Academy of Sciences

Acad. G. Bonchev Street, Bl. 9
BG-1113 Sofia, Bulgaria

Tel.:      +359 (2) 96 06 146
Fax:      +359 (2) 870 02 25


  • 1957 Born in Sofia, Bulgaria.
  • 1983 M.Sc., Faculty of Chemistry, University of Sofia.
  • 1993 Ph.D., Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia.
  • 1997 Senior Research Associate at the Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences.
  • 2003 Associate Professor at the Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences.

Visiting fellowships:

1995- 1997  Royal Society Postdoctoral Fellow at Department of Chemistry, Queen Mary, University of London. Topic: Investigation and characterisation of soil organic matter by solid and liquid state NMR spectroscopy.

Research Interests:

The use of solution and solid state NMR spectroscopy to study structure and stereochemistry of synthetic and natural organic compounds (carbohydrates, lipids, antibiotics, nucleotides, flavonoids, terpenoids, alkaloids etc.) in combination with other spectral, theoretical and chemical methods.

Current research topics include:
  • Structural analysis of fatty acids and glycerolipids by NMR spectroscopy: fatty acid composition and their positional distribution in the triacylglycerol molecule, oxidation stability of edible oils and fats, detection and identification of the oxidation products.
  • Application of NMR spectroscopy for structural and stereochemical studies of synthetic and natural biologically active compounds.
  • The use of NMR spectroscopy to study colloidal and water soluble temperature-responsive polymer systems, which have potential use as drug carriers. Study of possible mechanisms of drug immobilization in the polymer matrix.
  • Study of the tautomeric equilibrium in derivatives of cyclic diketones with potential UV-protecting activity by NMR and theoretical methods.
  • The use of NMR to study structure of linear and branched fluorescent polymers for application in optoelectronics.

Membership in Scientific Organizations:
  • Member of the Union of Scientists in Bulgaria
  • Member of the Bulgarian Chemical Society
  • Founding Member  of the non-profit  legal entity "Bulgarian Society for Organic and  Metaloorganic Chemistry"  founded in March  2004 with the purpose dissemination of scientific results and support of young scientists.

Selected Publications:

•    Proton and Carbon Chemical Shift Assignment and Solution State Conformation of the Macrolid Antibiotic Tylosin in Aprotic Solvents. S. Simova, G. I. Ivanova, Magn. Res. Chem. 34 (1996) 255.
•    Stereochemical Studies of 1,2-Di(thio)acetamidocyclohexanes and their N,N’-Dimethyl Derivatives by NMR and CD Spectroscopy and by Molecular Mechanics Calculations. A. Z. Khan, G. I. Ivanova, S. L. Spassov and J. Sandstroem, Acta Chem. Scand., 50 (1996) 938.
•    NMR Studies of Soil, Soil Organic Matter and Nutrients: Spectroscopy and Imaging. E. W. Randall, N. Mahieu, G. I. Ivanova, Geoderma, 80 (1997) 307.
•    Ab initio quantum chemical and NMR study of the symmetric monooximes of 1,2,3-phenalentrione and 1,2,3-indantrione. V. Enchev, G. Ivanova, A. Ugrinov, G. Neykov, S. Minchev, N. Stoyanov, J. Mol. Struct., 440 (1998) 227.
•    Tautomeric and Conformational Equilibrium of Acenaphthenequinone-mono- oxime. V. Enchev, G. Ivanova, A. Ugrinov, G. D. Neykov,  J. Mol. Struct., 508 (1999) 149.
•    Synhesis and beta-Lactamase Iinhibitory Activity of New 6-beta-Cysteine- sulfon- amidopenicillanic Acids. L. S. Changov, E. D. Najdenova, G. I. Ivanova, R. T. Gergova, E. E. Keuleyan, B. V. Aleksiev, Bioorganic and Medicinal Chemistry, 7 (1999) 2899.     
•    1H and 13C NMR study of soil organic matter at 14.1 T. G. Ivanova and  E. W. Randall, Bulgarian Chemical Communications, 31 (1999) 172.   
•    Does tautomeric equilibrium exist in ortho-nitrosonaphthols? G. Ivanova, V. Enchev, Chem. Phys., 264 (2001) 235.
•    Quantum chemical and spectroscopic study of 2-acetylindan-1, 3-dion complexes with metal(II) ions. V. Enchev, A. Ahmedova, G. Ivanova, I. Wawer, N. Stoyanov, M. Miteva,  J. Mol. Struct., 595 (2001) 67.
•    Structure of the symmetric monooxime of 1,2,3-indantrione in gas, solution and solid state. G. Ivanova, I. Abrahams, V. Enchev, J. Mol. Struct., 608 (2002) 193.
•    13C NMR and Mass Spectrometry of Soil Organic Matter. G. Ivanova, E. W. Randall, Central European Journal of Chemistry, 1 (2003) 10.
•    Reaction of 2-acetyl-indan-1,3-dione with aniline – Schiff base or enamine? V. Enchev, G. Ivanova, G. Pavlovic, M. Rogojerov, A. Ahmedova, M. Miteva, J. Mol. Struct., 654, (2003) 11.
•    Photophysical and photochemical properties of some 3-bromo-4-alkylamino- N-alkyl-1,8-  naphthalimides. V. Bojinov, G. Ivanova, J. Chovelon, I. Grabchev, Dyes and Pigments, 58 (2003) 65.
•    Water soluble temperature-responsive poly(vinyl alcohol-co-vinylacetal)s. D. Christova, S. Ivanova, G. Ivanova, Polymer Bulletin, 50 (2003) 367.
•    Poly(amidoamine) Dendrimers Peripherally Modified with 4-Ethylamino- 1,8-Naphthalimide. I. Grabchev, J. Chovelon, V. Bojinov, G. Ivanova, Tetrahedron, 59 (2003) 9591.
•    Alternative NMR Methods for quantitative determination of acyl positional distribution in triacylglycerols and related compounds. S. Simova, G. Ivanova, S.L. Spassov, Chem. Phys. Lip., 126 (2003) 111.
•    Poly(butylcyanoacrylate)nanoparticles as a topical drug delivery system for 5- fluorouracil.  M. Simeonova , R. Velichkova, G. Ivanova, V. Enchev, I. Abrahams, International Journal of Pharmaceutics, 263 (2003) 133.
•    Tautomeric and conformational equilibrium of 2-nitrosophenol and 9,10- phenanthrene- quinonemonooxime – an ab initio and NMR study. V. Enchev, G. Ivanova, N. Stoyanov, J. Mol. Struct.: THEOCHEM, 640 (2003) 149.
•    Study on the role of 5-fluorouracil in the polymerization of butylcyanoacryla- te during the formation  of nanoparticles. M. Simeonova, R. Velichkova, G. Ivanova, V. Enchev, I. Abrahams, Journal of Drug Targeting, 12 (2004) 49.
•    Synthesis and Photophysical Investigations of Novel Polymerizable Blue Emitting Fluorophores-Combination of a Hindered Amine with a Benzo[de]isoquinoline-1,3-dione. V. Bojinov, G. Ivanova, D. Simeonov,  Macromol. Chem. Phys., 205 (2004) 1259.