Laboratory Organic Synthesis and Stereochemistry,
The Group of Vladimir Dimitrov



Prof. D.Sc. Vladimir Dimitrov
Institute of Organic Chemistry
with Centre of Phytochemistry,
Bulgarian Academy of Sciences,
Acad. G. Bonchev Street, Bldg. 9,
BG-1113 Sofia, Bulgaria
Tel.: +359 (2) 96 06 157
Fax: +359 (2) 870 02 25
E-mail: vdim@orgchm.bas.bg

 		Vladimir Dimitrov


Born 1953 in Sofia, Bulgaria; 1977 Diploma in synthetic organic chemistry at the Technical
University Leuna-Merseburg, Germany (now Martin-Luther University Halle-Wittenberg);
1981 Doctoral degree (Dr. rer. nat.) at the Technical University Leuna-Merseburg with
K.-H. Thiele; 1982-88 Independent research at the Institute of Organic Chemistry of the
Bulgarian Academy of Sciences, since 1985 group and project leader; 1989-90 Fellow of
the Alexander von Humboldt Foundation at the Max-Planck-Institut für Kohlenforschung
Mülheim/Ruhr with H. Lehmkuhl; 1991-98 Group leader at the Institute of Organic
Chemistry of the Bulgarian Academy of Sciences (since 1997 Associate Professor);
1999-2001 Senior research fellow at the Institute of Organic Chemistry, University of Zürich
with M. Hesse; 2001-2004 Associate Professor at the Institute of Organic Chemistry of
the Bulgarian Academy of Sciences, Dr.sc.nat. (2002); Since 2003 Deputy Director of
the Institute; Since november 2004 Professor at the Institute;
Member of European Association for Chemical and Molecular Sciences (EuCheMS),
Division of Organometallic Chemistry; Member of the American Chemical Society;
President of the non-profit non-governmental legal entity "Bulgarian Society for Organic
and Organometallic Chemistry" founded in March 2004 with the purpose of dissemination
of scientific information, support of young scientists and organization of conferences;
Since 2005 head of Laboratory of Organic Synthesis and Stereochemistry at the institute




Research Interests:

Organic and organometallic chemistry; Application of organometallics to organic chemistry;
Synthesis of chiral ligands; Asymmetric synthesis of pharmaceutically relevant and natural
compounds; Application of mass-spectrometric techniques (ESI- and APCI-MSn,
HPLC/ACPI-MS/MS etc.) for the investigation of natural products.

Teaching activities:

Lecturer at the Faculty of Chemistry, University of Sofia (master degree).
Lectures available for downloading here in PDF or Power Point files.

Group Members:

The Group of Vladimir Dimitrov

NameOffice PhoneE-mail
Dr. Kalina Kostova+359 (2) 9606 154kalina@orgchm.bas.bg
Dr. Irena Philipova+359 (2) 9606 152irena@orgchm.bas.bg
Dr. Georgi Stavrakov+359 (2) 9606 117gstavrakov@orgchm.bas.bg
Dr. Malinka Stoyanova+359 (2) 9606 117mstoyanova@orgchm.bas.bg
Krasimira Petkova+359 (2) 9606 157petkova@orgchm.bas.bg
Mariana Kamenova+359 (2) 9606 134anmari@orgchm.bas.bg
Georgi Dobrikov+359 (2) 9606 152gmdob@orgchm.bas.bg
Angel Chimov+359 (2) 9606 134chimov@orgchm.bas.bg
Maya Tavlinova+359 (2) 9606 154maya@orgchm.bas.bg
Irena Sheytanova+359 (2) 9606 157irenash@orgchm.bas.bg


Selected publications:

  • V. Dimitrov, S. Bratovanov, S. Simova, K. Kostova, Tetrahedron Lett.
     1994, 35, 6713-6716. Cerium(III) Chloride as Catalytic and Stoichiometric Promoter
    of the Quantitative Addition of Organometallic Reagents to (+)-Camphor and (-)-Fenchone.

  • V. Dimitrov, K. Kostova, M. Hesse, Tetrahedron: Asymmetry 1994, 5, 1891-1894.
    Synthesis of New Optically Activ 1,3-Diols with Camphor and Fenchone Skeleton.

  • V. Dimitrov, S. Simova, K. Kostova, Tetrahedron 1996, 52, 1699-1706.
    Highly Effective and Practical Stereoselective Synthesis of New Homoallylic Alcohols with
    (+)-Camphor and (-)-Fenchone Skeleton.

  • V. Dimitrov, I. Philipova, S. Simova, Tetrahedron: Asymmetry 1996, 7, 1493-1500.
    Synthesis and Absolute Configuration of New Chiral Epoxyalcohols by Stereoselective
    Epoxidation of Allylic and Homoallylic Alcohols with a (1R)-(+)-Camphor Skeleton.

  • H. Lehmkuhl, V. Dimitrov, J. Organomet. Chem. 1996, 519, 83-85. Darstellung von
    η3-Allyl-1-Norbornyl-Komplexen des Nickels und Palladiums.

  • H. Lehmkuhl, V. Dimitrov, J. Organomet. Chem. 1996, 519, 69-73.
    η2-Alkin-Komplexe des η5-Cyclopentadienylnickel-1-norbornyls.

  • V. Dimitrov, K. Kostova, M. Genov, Tetrahedron Lett. 1996, 37, 6787-6790. Anhydrous
    Cerium(III) Chloride - Effect of the Drying Process on Activity and Efficiency.

  • V. Dimitrov, M. Genov, S. Simova, A. Linden, J. Organomet. Chem. 1996, 525, 213-224.
    Cerium(III) Chloride Mediated Addition of Mono- and Dilithium Ferrocene to (+)-Camphor
    and (-)-Fenchone - Synthesis and Structure of New Chiral Ferrocenyl Alcohols and Diols.

  • M. Genov, K. Kostova, V. Dimitrov, Tetrahedron: Asymmetry 1997, 8, 1869-1876.
    Highly diastereoselective synthesis of new optically active aminoalcohols in one step from
    (+)-camphor and (-)-fenchone.

  • M. Genov, V. Dimitrov, V. Ivanova, Tetrahedron: Asymmetry 1997, 8, 3703-3706.
    New δ-aminoalcohol for the enantioselective addition of dialkylzincs to aldehydes.

  • I. Philipova, V. Dimitrov, S. Simova, Tetrahedron: Asymmetry 1999, 10, 1381-1391.
    Synthesis of new enantiopure aminodiols and their use as ligands for the addition of
    diethylzinc to benzaldehyde.

  • K. Kostova, V. Dimitrov, S. Simova, M. Hesse, Helv. Chim. Acta 1999, 82, 1385-1399.
    Preparation of Chiral Hydroxy Carbonyl Compounds and Diols by Ozonolysis of Olefinic
    Isoborneol and Fenchol derivatives: Characterization of Stable Ozonides by 1H-, 13C-
    and 17O-NMR and Electrospray Ionization Mass Spectrometry.

  • V. Dimitrov, S. Panev, Tetrahedron: Asymmetry 2000, 11, 1513-1516.
    First example of axial selectivity in the nucleophilic addition to (-)-menthone -
    addition of cyanomethyl lithium.

  • S. Panev, V. Dimitrov, Tetrahedron: Asymmetry 2000, 11, 1517-1526.
    Cerium(III) chloride promoted addition of organometallic reagents to (-)-menthone -
    preparation of chiral neomenthyl derivatives.

  • K. Kostova, M. Genov, I. Philipova, V. Dimitrov, Tetrahedron: Asymmetry 2000,
    11, 3253-3256. New bis-steroidal axially chiral diols as ligands for the asymmetric
    addition of dialkylzinc to aldehydes.

  • S. Panev, A. Linden, V. Dimitrov, Tetrahedron: Asymmetry 2001, 12, 1313-1321.
    Chiral aminoalcohols with menthane skeleton as catalysts for the enantioselective addition of
    diethylzinc to benzaldehyde.

  • V. Dimitrov, A. Linden, M. Hesse, Tetrahedron: Asymmetry 2001, 12, 1331-1335.
    Chiral ferrocenes derived from (+)-longifolene - determination of the configuration by NMR
    spectroscopy and X-ray crystallography.

  • V. Dimitrov, H. Geneste, A. Guggisberg, M. Hesse, Helv. Chim. Acta 2001, 84, 2108-2118.
    Biomimetic Formation of Macrocyclic Spermine Alkaloids.

  • I. Kostova, D. Dinchev, G. Hopp Rentsch, V. Dimitrov, A. Ivanova, Z. Naturforsch. 2002,
    57c, 33-38. Two New Sulfated Furostanol Saponins from Tribulus terrestis.

  • V. Dimitrov, G. Hopp Rentsch, A. Linden, M. Hesse, Helv. Chim. Acta 2003, 86, 106-121.
    The Ozonolysis of Longifolene: A Tool for the Preparation of Useful Chiral Compounds.
    Configuration Determination of New Stereogenic Centers by NMR Spectroscopy and X-ray
    Crystallography.

  • V. Dimitrov, A. Linden, Angew. Chem. Int. Ed. 2003, 42, 2631. A Pseudo-tetrahedral
    High Oxidation State Organonickel Compound: Synthesis and Structure of
    Bromo-tris(1-norbornyl)nickel(IV).


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Last Update: 20 Mar 2006