Last update:

25 september 2019



Assoc Prof. Svilen Simeonov, PhD
Institute of Organic Chemistry
with Centre of Phytochemistry,
Bulgarian Academy of Sciences,
Acad. G. Bonchev Street, Bldg. 9,
BG-1113 Sofia, Bulgaria
Tel.: +359 (2) 96 06 114
Fax: +359 (2) 870 02 25
E-mail: svilen@orgchm.bas.bg

Svilen Simeonov studied chemistry at the Faculty of Chemistry, University of Sofia, Bulgaria where he received in 2004 his MSci in Organic chemistry. From March 2004 to December 2005 he worked in “Unipharm” JSCo, Department of Quality Control, Bulgaria. In January 2006 he joined academia at the Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences as an assistant researcher. In 2010 he moved to Instituto Superior Técnico – CQFM, Lisbon and later to Pharmacy Faculty of the Lisbon University where in 2014 he received his PhD in organic chemistry under the supervision of Prof. Carlos Afonso. In fall 2014 he return to the Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences where in 2016 he received his habilitation in Organic Chemistry and was appointed associate professor at Laboratory “Organic Synthesis and Stereochemistry”. From 2017 he holds the position of the head of Laboratory “Organic Synthesis and Stereochemistry”.

Awards and distinctions
2015 – UNESCO/PhosAgro/ IUPAC, Green Chemistry for Life award for young scientists
2010 – FCT PhD scholarship - SRFH/BD/67025/2009


  1. S. Simeonov, H. Lazarova, M. Marinova, M. Popova, Achmatowicz rearrangement enables hydrogenolysis–free gas-phase synthesis of pentane-1,2,5-triol from furfuryl alcohol, Green Chem., 2019, ASAP, DOI 10.1039/C9GC02888A
  2. J. Ravasco, C. Monteiro, F. Siopa, A. Trindade, J. Oble, G. Poli, S. Simeonov, C. Afonso, Creating diversity from biomass: a tandem bio/metal-catalysis towards chemoselective synthesis of densely substituted furans, ChemSusChem, 2019, ASAP, DOI: 10.1002/cssc.201902051, highlighted as VIP
  3. S. Simeonov, M. Ravutsov, M. Mihovilovic, Biorefinery via achmatowicz rearrangement: synthesis of pentane‐1,2,5‐triol from furfuryl alcohol, ChemSusChem, 2019, 12, 2748 –2754.
  4. R. Gomes, Y. Mitrev, S. Simeonov,* C. Afonso,* Going Beyond the Limits of the Biorenewable Platform: Sodium Dithionite‐Promoted Stabilization of 5‐Hydroxymethylfurfural, ChemSusChem, 2018, 11, 1612 –1616. highlighted as VIP
  5. V. Gawali, S. Simeonov, M. Drescher, T. Knott, O. Scheel, J. Kudolo, H. Kählig, U. Hochenegg, A. Roller, H. Todt, N. Maulide, C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers, ChemMedChem, 2017, 12, 1819-1822.
  6. S. Simeonov, S. Simova, B. Schivachev, R. Nikolova and V. Kurteva, Solution and solid state characterization of “sparteine surrogate”(+)-(1R,5S,11aS)-tetrahydrodeoxocytisine, Bulg. Chem. Commun.,2017, 49, 103-110.
  7. J. Ravasco, J. Coelho, S.Simeonov and C.Afonso, Bifunctional Cr3+ modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose, RSC Adv., 2017,7, 7555-7559.
  8. A. Vicente, J. Coelho, S. Simeonov, H. Lazarova, M. Popova and C. Afonso, Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF), Molecules, 2017, 22, 329-343..
  9. S. Simeonov, J. Nunes, K. Guerra, V. Kurteva and C. Afonso, Synthesis of Chiral Cyclopentenones, Chem. Rev., 2016, 116 , 5744–5893.
  10. S. Simeonov, J. Coelho and C. Afonso, Synthesis of 5-(Hydroxymethyl)furfural (HMF), Org. Synth., 2016, 93, 29-36.
  11. S. Simeonov and C. Afonso, Basicity and Stability of the Urea Deep Eutectic Mixtures, RSC Adv., 2016, 6, 5485-5490
  12. L. Antonov, V. Deneva, S. Simeonov, V. Kurteva, A. Crochet, K. M. Fromm, B. Shivachev, R. Nikolova, M. Savarese and C. Adamo, Controlled tautomeric switching in azonaphthols - tune by substituents in the phenyl ring, ChemPhysChem, 2015, 16, 649-657.
  13. R. Frade, J. Coelho, S. Simeonov and C. Afonso, Emerging Platform from Renewable Resources: Selection Guidelines for Human Exposure of Furan-Based Compounds, Toxicol. Res., 2014, 3, 311-314.
  14. A. Martins, S. Simeonov, L. Frija, R. Viveiros, A. Lourenço, M. da Silva, T. Casimiro and C.Afonso, Isolation, analytical quantification and seasonal variation of labdanolic acid from the Portuguese-grown Cistus ladaniferus. Ind. Crop. Prod., 2014, 60, 226-232.
  15. S. Simeonov, J. Coelho and C. Afonso, Integrated chemo-enzymatic production of 5-hydroxymethylfurfural from glucose, ChemSusChem, 2013, 6, 997-1000.
  16. R. Frade, S. Simeonov, A. Rosatella, F. Siopa and C. Afonso, Toxicological evaluation of magnetic ionic liquids in human cell lines, Chemosphere, 2013, 92, 100-105.
  17. S. Subbiah, S. Simeonov, J. Esperança, L. Rebelo and C. Afonso, Direct transformation of
    5-hydroxymethylfurfural to the building blocks 2,5-dihydroxymethylfurfural (DHMF) and
    5-hydroxymethyl furanoic acid (HMFA) via Cannizzaro reaction, Green Chem., 2013, 15, 2849-2853.
  18. S. Simeonov and C. Afonso, Batch and Flow Synthesis of 5-Hydroxymethylfurfural (HMF) from Fructose as a Bioplatform Intermediate: An Experiment for the Organic or Analytical Laboratory, J. Chem. Edu., 2013, 90, 1373-1375.
  19. M. Zakrzewska, A. Rosatella, S. Simeonov, C. Afonso, V. Najdanovic-Visaka and M. da Pontea, Solubility of carbon dioxide in ammonium based CO2-induced ionic liquids, Fluid Phase Equilib., 2013, 324, 19-23.
  20. I. de Pedro, A. Garcia-Saiz, J. Gonzalez, I. de Larramendi, T. Rojo, C. Afonso, S.Simeonov, J. Waerenborgh, J. Blanco, B. Ramajo and J. Fernandez, Magnetic ionic plastic crystal: choline[FeCl4], Phys. Chem. Chem. Phys., 2013, 15, 12724-12733.
  21. A. Ahmedova, S. Simeonov, V. Kurteva and L. Antonov, Tautomerism of 4,4′-dihydroxy-1,1′-naphthaldazine studied by experimental and theoretical methods, Chemistry Central Journal, 2013, 7-29.
  22. S. Simeonov, J. Coelho and C. Afonso, Integrated Simple Approach for the Production and Isolation of 5-Hydroxymethylfurfural (HMF) from Carbohydrates, ChemSusChem , 2012, 5, 1388-1391.
  23. J. Albo, E. Santos, L. Neves, S. Simeonov, C. Afonso, J. Crespo and A. Irabien, Separation performance of CO2 through Supported Magnetic Ionic Liquid Membranes (SMILMs), Sep. Purif. Technol., 2012, 97, 26-33.
  24. A. Rosatella, S. Simeonov, R. Frade and C. Afonso, 5-Hydroxymethylfurfural (HMF) a building block platform: Biological properties, Synthesis and synthetic applications, Green Chem., 2011, 13, 754-793. Green Chem. top ten most accessed articles in 2012. Green Chem. top cited articles in 2011.
  25. L. Antonov, V.Kurteva, S. Simeonov, V. Deneva, A. Crochet and K. Fromm, Tautocrowns: A Concept For A Sensing Molecule With An Active Side-Arm, Tetrahedron, 2010, 66, 4292-4297.
  26. L. Antonov, V. Deneva, S. Simeonov, V. Kurteva, D. Nedeltcheva and J. Wirz, Exploiting tautomerism for switching and signaling, Angew. Chem., Int. Ed., 2009, 48, 7875-7878.


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