Laboratory of Organic Synthesis and Stereochemistry,
Institute of Organic Chemistry with Centre of Phytochemistry,
Bulgarian Academy of Sciences
Prof. D.Sc. Vladimir Dimitrov, Head of the Laboratory,
Institute of Organic Chemistry with Centre of Phytochemistry,
Bulgarian Academy of Sciences,
Acad. G. Bonchev Street, Bldg. 9,
BG-1113 Sofia, Bulgaria
Tel.: +359 (2) 96 06 157
Fax: +359 (2) 870 02 25
E-mail: vdim@orgchm.bas.bg
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- Research Topics:
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- Stereoselective C-C-bond forming reactions (aldol and Michael reactions; metal mediated addition
reactions to carbonyl compounds; alkylation reactions of metal enolates bearing an adjacent
stereogenic center; Suzuki coupling reactions); Investigations on the intramolecular catalytic
aldol cyclodehydration of 1,6-dialdehydes;
- Design of new chiral catalysts for asymmetric transformations based on ligands synthesized by
use of readily available chiral sources (camphor, fenchone, menthone, longifolene etc.);
- Design of multifunctional ferrocene derivatives possessing center and plane of chirality for
development of new chiral catalysts and materials;
- Synthesis of multifunctional organic compounds – compounds possessing biological activity,
building blocks, compounds with fluorescent properties, calixarenes with phosphinoyl type
ligating groups at the narrow rim etc;
- Solventless synthesis of heterocyclic compounds under microwaves – triazines, tetrazines,
pyrimidines, azetidines etc.;
- Chemistry of cyanine dyes; Application of organometallics in the cyanine chemistry;
Cyanines based ligands systems.;
- Groups:
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- The group of Vladimir Dimitrov
- The group of Lilia Viteva
- The group of Vanya Kurteva
- Microanalytical laboratory for elemental analysis
- Projects:
- Current financial support by Bulgarian National Science Fund (X-1506) and
Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung (SCOPES 2005-2008);
- Facilities:
- 8 laboratories equipped for synthesis of organic and organometallic compounds (argon/vacuum lines
for manipulation of air and moisture sensitive compounds);
- Glove box;
- High vacuum pumping unit;
- Ozonization apparatus;
- HPLC HP Agilent 1100;
- GC Shimadzu GC-17A with APC and autosampler;
- Polarimeter Perkin-Elmer 241;
- Spectrophotometer Specord UV/VIS;
- Laboratory Members:
- Selected publications:
- L. Viteva, Y. Stefanovsky, Ch. Tsvetanov and L. Gorrichon, J. Phys. Org. Chem., 1990, 3, 205.
Triple Ion Chelate Structure of an Equilibrium Michael Adduct.
- L. Viteva and Y. Stefanovsky, J. Chem. Res. (S), 1990, 232.
The Michael Addition of Alkyl Phenylacetate Enolates to Cinnamic Acid Esters:
Stereochemistry and Mechanism.
- L. Viteva and Y. Stefanovsky, Tetrahedron Lett., 1990, 31, 5649.
Michael Addition of Phenylacetic Acid Dialkylamides and Ester Enolates to
Z-Methyl Cinnamate. Dependence of the Stereochemistry on the Acceptor Geometry.
- R. Stefanova, L. Viteva and Y. Stefanovsky, J. Mol. Struct., 1992, 271, 251.
NMR Study of the Conformational Distribution in Methyl Esters and N,N-Dimethylamides
of Diastereoisomeric 4-Cyano-3,4-diphenyl- and 4-Cyano-3-phenyl-4-(1-naphtyl)-butyric acids.
Relation to the Configurations.
- L. Viteva, Ts. Gospodova and Y. Stefanovsky, Phosphorous, Sulfur and Silicon, 1993, 78, 189.
N,N-Dialkylthioamides in the Michael Addition to Conjugate Carbonyl Compounds,
Regioselectivity, Stereochemistry and Mechanism.
- L. Z. Viteva, Ts. S. Gospodova and Y. N. Stefanovsky, Tetrahedron, 1994, 50, 7193.
Titanium enolates and “ate” Complexes of N,N-Disubstituted
Amides and Thioamides in the Michael Reaction.
- L. Viteva and L. Gorrichon, Mh. Chem., 1995, 26, 1001.
Kinetic Assymetric Protonation as a Stereochemistry Determining Step in the Michael Addition of Acetic to
α-Substituted Cinnamic Acid Derivatives.
- L. Viteva, Y. Stefanovsky, Ts. Gospodova, M.-R. Maziers, J.-G. Wolf, Tetrahedron Lett., 2000, 41, 2541.
First example of lithium reagents addition to cyanine dyes series.
- L. Z. Viteva, Tz. S. Gospodova, Y. N. Stefanovsky, J. Chem. Res. (S), 2000, 133.
Stereochemistry of aldoll condensation of N,N-dialkyl amides with aromatic imines.
Highly diastereoselective synthesis of β-amino acid dialkylamides.
- L. Viteva, Tz. Gospodova, Y. Stefanovsky, M.-R. Mazieres, J.-G. Wolf, Tetrahedron Lett., 2001, 42, 7945.
Nucleophilic addition of organolithium reagents to cyanine dyes. A new access to functionalized hexatrienes.
- L. Viteva, Tz. Gospodova, Y. Stefanovsky, S. Angelova and L. Gorrichon, Tetrahedron, 2002, 58, 3371.
Diastereoselectivity of tandem Michael addition-alkylation reactions:
a convenient method for one-pot synthesis of α-branched 2,3-diphenylglutaric acid derivatives.
- L. Viteva, Tz. Gospodova, Y. Stefanovsky, K. Petrova, I. Timtcheva,
M-R. Mazieres, J.-G. Wolf, Eur. J. Org. Chem. 2004, 385.
Organometallics in Cyanine Chemistry – Synthesis, Reactivity and Photophysical Properties of
some Heptamethine Merocyanine Dyes.
- L. Viteva, Tz Gospodova, Y. Stefanovsky and S. Simova, Tetrahedron, 2005, 61, 5855.
Diastereoselectivity in addition of nitrile-stabilized carbanions to Schiff bases and
in subsequent alkylation reactions.
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Last Update: 23 Jan 2008
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